Hair Mercury Negatively Correlates with Calcium Pump Activity in Human Term Newborns and Their Mothers at Delivery
نویسندگان
چکیده
BACKGROUND Calcium homeostasis is a known target of several environmental toxicants including lead and mercury. OBJECTIVE Our goal was to determine the relationship between Hg exposure and erythrocyte Ca pump activity in women at delivery and in their newborns. METHODS We determined total Hg as well as Pb concentrations in 81 hair and blood samples obtained at delivery. Basal and calmodulin-stimulated Ca pump activity was measured in red blood cells from cord blood and maternal erythrocyte plasma membranes. RESULTS Maternal hair Hg negatively correlates with Ca pump activity in maternal and cord blood erythrocytes. Pb and Hg both independently correlate negatively with Ca pump activity without any statistically significant interaction. After adjustment for potential confounders, Pb and Hg explain about 30% and 7% of total variance of Ca pump activity in newborns and mothers, respectively. CONCLUSION Our findings confirm results reported in previous experimental studies and support the use of biomarkers in newborns from general population.
منابع مشابه
Mercury in Hair of Mothers and Infants: Influencing Factors Assessment in the Southern shores of the Caspian Sea (Iran)
Background: Mercury (Hg) is a hazardous metal responsible for environmental contamination and human intoxication. Methyl mercury bio-accumulation through food chain can be responsible for chronic mercury exposure of South Caspian Sea communities with a diet rich in fish. Uncertainties about exposure levels that could have damaging consequences for nervous system development of infants makes b...
متن کاملسنجش جیوه موجود در موی مادران شیرده وارتباط آن با متغیرهای مصرف ماهی، تعداد دندان های پر شده با آمالگام، سن و محل زندگی
Backgrounds and Objectives: Mercury is a heavy metal that is widespread in the environment and has many toxic effects. At present, MeHg exposure on women remain an important issues for researching, especially those of continuous uptake in high-fish consumption.MeHg can be transferred to infant through breast milk. The objective of this study was to characterize the risk of Hg exposure in mother...
متن کاملThe Effect of Maternal Thyroid Disorders (Hypothyroidism and Hyperthyroidism) During Pregnancy and Lactation on Skin Development in Wistar Rat Newborns
Objective(s): Previous studies have shown that thyroid hormones are necessary for normal development of many organs and because of the importance of skin as the largest and the most important organ in human body protection in spite of external environment, the study of thyroid hormones effects on skin development is considerable. In this survey we have tried to study the effects of maternal h...
متن کاملتجمع جیوه در مو و ناخن انسان: آمالگام دندانی به عنوان فاکتور اصلی مواجهه
Background: Dental amalgam, a mixture of approximately 50% mercury with silver, tin, zinc and copper in varying ratios, is a major source of mercury pollution in the general population not occupationally exposed. The toxicity of mercury is enhanced because it is so readily absorbed, with around 90-100% of mercury vapor being absorbed through the oral mucosa. The aim of the current study is to e...
متن کاملThe Relationship Between Maternal Serum Levels of Calcium, Phosphorus and Magnesium with Preterm Labor: A Case-Control Study
Introduction: Preterm delivery is one of the essential midwifery problems, which causes a large proportion of infant mortality even in advanced societies. Despite advances in pregnancy care, the frequency of preterm delivery has not decreased. This study aimed to determine the relationship between serum calcium, phosphorus, and magnesium level with preterm labor in pregnant women. Methods: In ...
متن کامل